Protective role of seleno-amino acid against IBD via ferroptosis inhibition in enteral nutrition therapy

作者：Shuchen Huangfu, Jie Zheng, Jiashuai He, Jin Liao, Haiping Jiang, Hua Zhou, Jinghua Pan · 发表于：iScience · 年份：2024 · DOI：10.1016/j.isci.2024.110494 · 被引用次数：8 · 研究领域：Selenium in Biological Systems、Ferroptosis and cancer prognosis、Trace Elements in Health

, enteral nutrition combined with seMc protected the intestinal barrier and alleviated IBD-related symptoms by inhibiting ferroptosis and reversing lipid peroxidation in epithelial cells while reducing immune cell infiltration. Our findings suggest that seleno-amino acid-based nutritional formulations may provide a basis for nutritional support to alleviate complex cycles between intestinal barrier damage and malnutrition in IBD patients.