Untargeted faecal metabolomics for the discovery of biomarkers and treatment targets for inflammatory bowel diseases

作者：Arnau Vich Vila, Jingwan Zhang, Moting Liu, Klaas Nico Faber, Rinse K. Weersma · 发表于：Gut · 年份：2024 · DOI：10.1136/gutjnl-2023-329969 · 被引用次数：92 · 研究领域：Gut microbiota and health、Metabolomics and Mass Spectrometry Studies、Ginseng Biological Effects and Applications

The gut microbiome has been recognised as a key component in the pathogenesis of inflammatory bowel diseases (IBD), and the wide range of metabolites produced by gut bacteria are an important mechanism by which the human microbiome interacts with host immunity or host metabolism. High-throughput metabolomic profiling and novel computational approaches now allow for comprehensive assessment of thousands of metabolites in diverse biomaterials, including faecal samples. Several groups of metabolites, including short-chain fatty acids, tryptophan metabolites and bile acids, have been associated with IBD. In this Recent Advances article, we describe the contribution of metabolomics research to the field of IBD, with a focus on faecal metabolomics. We discuss the latest findings on the significance of these metabolites for IBD prognosis and therapeutic interventions and offer insights into the future directions of metabolomics research.