A novel basement membrane-related gene signature predicts prognosis and immunotherapy response in hepatocellular carcinoma

作者：Bingyao Li, Yingkun Che, Puhua Zhu, Yuanpeng Xu, Haibo Yu, Deyu Li, Xiangming Ding · 发表于：Frontiers in Oncology · 年份：2024 · DOI：10.3389/fonc.2024.1388016 · 被引用次数：2 · 研究领域：Ferroptosis and cancer prognosis、Cell Adhesion Molecules Research、Immune cells in cancer

Background Basement membranes (BMs) have recently emerged as significant players in cancer progression and metastasis, rendering them promising targets for potential anti-cancer therapies. Here, we aimed to develop a novel signature of basement membrane-related genes (BMRGs) for the prediction of clinical prognosis and tumor microenvironment in hepatocellular carcinoma (HCC). Methods The differentially expressed BMRGs were subjected to univariate Cox regression analysis to identify BMRGs with prognostic significance. A six-BMRGs risk score model was constructed using Least Absolute Shrinkage Selection Operator (LASSO) Cox regression. Furthermore, a nomogram incorporating the BMRGs score and other clinicopathological features was developed for accurate prediction of survival rate in patients with HCC. Results A total of 121 differentially expressed BMRGs were screened from the TCGA HCC cohort. The functions of these BMRGs were significantly enriched in the extracellular matrix structure and signal transduction. The six-BMRGs risk score, comprising CD151 , CTSA , MMP1 , ROBO3 , ADAMTS5 and MEP1A , was established for the prediction of clinical prognosis, tumor microenvironment characteristics, and immunotherapy response in HCC. Kaplan-Meier analysis revealed that the BMRGs score-high group showed a significantly shorter overall survival than BMRGs score-low group. A nomogram showed that the BMRGs score could be used as a new effective clinical predictor and can be combined with...