Clinical pathological characteristics and expression of 328 proteins and their impact on survival in over 20,000 cases of esophageal squamous cell carcinoma and colorectal adenocarcinoma

作者：Lidong Wang, Qianqian Ding, Kan Zhong, Hui Sun, Zong-Min Fan, Jin Huang, Ningning Jiang, Jiayi Zhu, Fuyou Zhou, Shengli Zhou, Jiateng Zhong, Peinan Chen, Ruohua Zhao, Yuanyuan Li, Quanxiao Xu, Lei Ma, Wei Guo, Haijun Yang, Aili Li, Fuqiang Qin, Wen-Li Han, Lisha Chen, Huixiang Li, Jingli Ren, F. Xiao, Ling-Ling Lei, Rui‐Hua Xu, Mengxia Wei, Xueke Zhao, Xin Song, Ying Yuan, Shu Zheng · 发表于：Chinese Science Bulletin (Chinese Version) · 年份：2024 · DOI：10.1360/tb-2024-0291 · 被引用次数：1 · 研究领域：Esophageal Cancer Research and Treatment、Advanced Proteomics Techniques and Applications、Protease and Inhibitor Mechanisms

Esophageal squamous carcinoma and colorectal adenocarcinoma are both the most common digestive tract tumors in China, and they share certain similarities in genetic susceptibility, major risk factors and molecular mechanisms. However, comparative studies on these two tumors with large sample sizes are still lacking. This study was conducted to analyze the differences between the two tumors in clinicopathological features and tumor-associated protein expression, their impact on survival, and to provide a basis for the identification of molecular markers of early detection and targeted therapy. In this study, 26 tumor-associated proteins were selected from 20,097 patients with esophageal squamous carcinoma and colorectal adenocarcinoma. The χ 2 test was applied to compare the differences between the two tumors in terms of clinicopathological features and protein expression. The Kaplan-Meier survival analysis and Cox regression analysis were used to compare the relationship between the clinicopathological features and protein expression and the survival of patients. Significant differences were found between patients with esophageal squamous carcinoma and those with colorectal adenocarcinoma in gender, age, degree of differentiation, margins, TNM stage, vascular embolism, neurological invasion and family history. In addition, age, lymph node metastasis, TNM stage and degree of differentiation had similar effects on the prognosis of patients with both tumors, and gender had op...