Aryl hydrocarbon receptor confers protection against macrophage pyroptosis and intestinal inflammation through regulating polyamine biosynthesis

作者：Yajing Gao, Kwei-Yan Liu, Wenfeng Xiao, Xueru Xie, Qiuyan Liang, Zikun Tu, Lan Yang, Hongmiao Yu, Haiyan Guo, Saihua Huang, Xiao Han, Jinrong Fu, Yufeng Zhou · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.95749 · 被引用次数：41 · 研究领域：Immune Cell Function and Interaction、Heme Oxygenase-1 and Carbon Monoxide、Cannabis and Cannabinoid Research

These findings suggest a functional role for the AhR/ODC1/polyamine axis in maintaining intestinal homeostasis, providing potential targets for treatment of inflammatory bowel disease.