Ellagic acid-modified gold nanoparticles to combat multi-drug resistant bacterial infections in vitro and in vivo

作者：Yaran Wang, Fan Wu, Yuanfeng Li, Siran Wang, Yijin Ren, Linqi Shi, Henny C. van der Mei, Yong Liu · 发表于：Materials Horizons · 年份：2024 · DOI：10.1039/d4mh00642a · 被引用次数：20 · 研究领域：Essential Oils and Antimicrobial Activity、Nanoparticles: synthesis and applications、Bee Products Chemical Analysis

in mice compared to treatment with free EA or gentamicin. Moreover, transcriptome analysis revealed that EA-AuNPs exhibited a multi-targeting mechanism, making resistance development in pathogens more challenging than traditional antibiotics that recognize specific cellular targets. Overall, EA-AuNPs emerged as a promising antimicrobial agent against multi-drug-resistant bacterial infections.