From prenatal diagnosis to surgical treatment: two case reports of congenital granular cell epulis

作者：Yibing Han, Wen Qiu, Yu Zhang, Mengmeng Hua, Shaohua Liu, Zuoqing Dong · 发表于：Pathology & Oncology Research · 年份：2024 · DOI：10.3389/pore.2024.1611834 · 被引用次数：5 · 研究领域：Tumors and Oncological Cases、Oral and Maxillofacial Pathology、Soft tissue tumor case studies

Herein, we detail a multidisciplinary approach and sequential treatment for two infants with congenital granular cell epulis (CGCE). Ultrasonic examinations at 34 weeks of gestation revealed prominent oral masses in both fetuses. To devise a carefully considered treatment strategy, a comprehensive multidisciplinary consultation including oral and maxillofacial surgeons, pediatricians, obstetricians, and anesthesiologists was convened. Following cesarean sections, the lesions were successfully removed, measuring approximately 30 × 15 mm and 30 × 20 mm in size, respectively. Immunohistochemical analysis showed that vimentin was positive, S-100 protein was negative, and NSE protein and CD68 protein were negative. These findings underscore the importance of prenatal diagnosis of congenital granular cell epulis for the effective management of these rare benign conditions.