The atypical antipsychotics and sexual dysfunction: a pharmacovigilance-pharmacodynamic study

作者：Cheng Yu, Youjun Chen, Xue Zhao, Fan Mou, Wanying Wang, Ruiyi Qian, Jingjing Huang, Huafang Li, Qingqing Xu, Shunying Yu · 发表于：Frontiers in Pharmacology · 年份：2024 · DOI：10.3389/fphar.2024.1423075 · 被引用次数：12 · 研究领域：Pharmacovigilance and Adverse Drug Reactions、Schizophrenia research and treatment、Sexual function and dysfunction studies

Background Atypical antipsychotics (AAPs)-induced sexual dysfunction (SD) is a frequent issue in clinical practice, often underestimated by clinicians and not extensively researched. The current study aimed to quantify the strength of association between the use of different AAPs and SD using real-world data from the FDA Adverse Event Reporting System (FAERS), as well as investigate the receptor mechanisms that are involved. Methods Data from the FAERS database from the first quarter of 2004 to the third quarter of 2023 were queried through OpenVigil 2.1. Disproportionality analysis was estimated using the reporting odds ratio (ROR) and information component (IC) methods, and linear regression was used to investigate the relationship between ROR and receptor occupancy which was estimated using in vitro receptor binding profiles. Results Our analysis yielded 4839 reports that co-mentioned AAP and SD events, and the findings revealed statistical associations between 12 AAPs and SD. The highest signal value was identified for iloperidone reporting retrograde ejaculation with iloperidone (ROR = 832.09, ROR 025 = 552.77; IC = 9.58, IC 025 = 6.36), followed by compulsive sexual behavior with aripiprazole (ROR = 533.02, ROR 025 = 435.90; IC = 7.30, IC 025 = 5.97), and psychosexual disorder for aripiprazole (ROR = 145.80, ROR 025 = 109.57; IC 025 = 6.47, IC025 = 4.86). Different characteristics of the SD side effects in each AAPs were discovered after further data mining. Regression ...