Neurocysticercosis Prevalence and Characteristics in Communities of Sinda District in Zambia: A Cross-Sectional Study

作者：Gideon Zulu, Dominik Stelzle, Sarah Gabriël, Chiara Trevisan, Inge Van Damme, Chishimba Mubanga, Veronika M. Schmidt, Bernard James Ngowi, Tamara M. Welte, Pascal Magnussen, Charlotte Ruether, Agnès Fleury, Pierre Dorny, Emmanuel Bottieau, Isaac Khozozo Phiri, Kabemba Evans Mwape, Andrea Sylvia Winkler · 发表于：Journal of Epidemiology and Global Health · 年份：2024 · DOI：10.1007/s44197-024-00271-z · 被引用次数：10 · 研究领域：Parasitic infections in humans and animals、Parasitic Infections and Diagnostics、Cerebrospinal fluid and hydrocephalus

BACKGROUND: This study aimed at describing the epidemiology of (neuro)cysticercosis as well as its clinical and radiological characteristics in a Taenia solium endemic district of Zambia. METHODS: This was part of a cross-sectional community-based study conducted in Sinda district to evaluate an antibody-detecting T. solium point-of-care (TS POC) test for taeniosis and (neuro)cysticercosis. All TS POC cysticercosis positive (CC+) participants and a subset of the TS POC cysticercosis negative (CC-) received a clinical evaluation and cerebral computed tomography (CT) examination for neurocysticercosis (NCC) diagnosis and staging. RESULTS: Of the 1249 participants with a valid TS POC test result, 177 (14%) were TS POC CC+ . Cysticercosis sero-prevalence was estimated to be 20.1% (95% confidence intervals [CI] 14.6-27.0%). In total, 233 participants received a CT examination (151 TS POC CC+ , 82 TS POC CC-). Typical NCC lesions were present in 35/151 (23%) TS POC CC+ , and in 10/82 (12%) TS POC CC- participants. NCC prevalence was 13.5% (95% CI 8.4-21.1%) in the study population and 38.0% (95% CI 5.2-87.4%) among people reporting epileptic seizures. Participants with NCC were more likely to experience epileptic seizures (OR = 3.98, 95% CI 1.34-11.78, p = 0.01) than those without NCC, although only 7/45 (16%) people with NCC ever experienced epileptic seizures. The number of lesions did not differ by TS POC CC status (median: 3 [IQR 1-6] versus 2.5 [IQR 1-5.3], p = 0.64). Eight (2...