Key Issues of Economic Evaluations for Health Technology Assessment in China: A Nationwide Expert Survey

作者：Gordon G. Liu, Haijing Guan, Nan Peng, Shitong Xie, Kang Wang, Larry Z. Liu, Yanbing Zhou, Huajie Jin · 发表于：Value in Health · 年份：2024 · DOI：10.1016/j.jval.2024.06.020 · 被引用次数：12 · 研究领域：Health Systems, Economic Evaluations, Quality of Life、Pharmaceutical Economics and Policy、Healthcare Systems and Reforms

OBJECTIVES: Health technology assessment (HTA) is increasingly crucial in medicine price negotiations in China, yet previous appraisals revealed national discrepancies on key economic evaluation issues: willingness-to-pay threshold, pricing models for multi-indication medicines, and comparator selection principles. This study aimed to collect expert opinions on these issues for future HTA evaluations. METHODS: A nationwide anonymous web-based survey encompassing experts across academia, HTA, consultancy/contract research organization/industry, service provider, and payer. In 2023, a generic invitation containing a web link to the questionnaire was disseminated via WeChat using convenience and snowball sampling. Agreement rates for questionnaire views were analyzed using descriptive statistics. The relationship between participants' responses and demographics was examined using appropriate logistic models. RESULTS: A total of 303 responses were received from experts in 34 cities. Key expert views include a suggested base willingness-to-pay threshold ranging from 0.5 to 1.5 times gross domestic product (52.1% agreement); elevated thresholds for childhood diseases, rare diseases, end-of-life diseases, and first-in-class medicines (>78.0% agreement); a single pricing model for multi-indication medicines (60.4% agreement); consideration of multiple medicines as comparators (79.9% agreement); and avoiding the use of centrally procured medicines as comparators for medicines with a t...