代谢物衍生型损伤相关分子模式与自身免疫相关疾病

作者：Wanli Liu, Na Kang, S Liu, Qinghui Duan · 发表于：Chinese Science Bulletin (Chinese Version) · 年份：2024 · DOI：10.1360/tb-2024-0335 · 被引用次数：1 · 研究领域：Inflammasome and immune disorders、Endoplasmic Reticulum Stress and Disease、Fibroblast Growth Factor Research

Damage-associated molecular patterns (DAMPs) are endogenous molecules typically released from damaged or stressed cells that trigger inflammatory responses by activating DAMP receptors on immune cells. If these DAMPs are not promptly cleared, sustained inflammation can ensue, promoting the development and progression of autoimmune diseases. This review provides an in-depth overview of a specific class of metabolite-derived DAMPs, known as metabolism-associated molecular patterns (MAMPs). These MAMPs are derived from the metabolic pathways governing lipids, glucose, nucleotides, and amino acids. The molecular mechanisms by which these MAMPs contribute to inflammatory responses are thoroughly summarized, accompanied by a comprehensive exploration of their role in autoimmune diseases. The review begins by highlighting the critical role of MAMPs in initiating and sustaining inflammatory processes. Uncleared MAMPs can drive chronic inflammation, a hallmark of many autoimmune diseases. The authors then delve into the specific class of MAMPs, detailing how metabolites from lipid, glucose, nucleotide, and amino acid pathways can function as DAMPs. Through a detailed examination of the molecular mechanisms, the review elucidates how these MAMPs interact with receptors on immune cells to trigger inflammatory cascades. This provides important insights into the pathogenic contributions of MAMPs to the development and progression of autoimmune disorders. Shifting the focus to potential th...