PANoptosis: Novel insight into regulated cell death and its potential role in cardiovascular diseases (Review)

作者：Xinyu Gao, Cuixue Ma, Shan Liang, Meihong Chen, Yuan He, Wei Lei · 发表于：International Journal of Molecular Medicine · 年份：2024 · DOI：10.3892/ijmm.2024.5398 · 被引用次数：31 · 研究领域：Inflammasome and immune disorders、Biomarkers in Disease Mechanisms、Adipokines, Inflammation, and Metabolic Diseases

PANoptosis, a complex form of proinflammatory programmed cell death, including apoptosis, pyroptosis and necroptosis, has been an emerging concept in recent years that has been widely reported in cancer, infectious diseases and neurological disorders. Cardiovascular diseases (CVDs) are an important global health problem, posing a serious threat to individuals' lives. An increasing body of research shows that inflammation has a pivotal role in CVDs, which provides an important theoretical basis for PANoptosis to promote the progression of CVDs. To date, only sporadic studies on PANoptosis in CVDs have been reported and its role in the field of CVDs has not been fully explored. Elucidating the various modes of cardiomyocyte death, the specific molecular mechanisms and the links among the various modes of death under various stressful stimuli is of notable clinical significance for a deeper understanding of the pathophysiology of CVDs. The present review summarizes the molecular mechanisms of apoptosis, pyroptosis, necroptosis and PANoptosis and their prospects in the field of CVDs.