The functions and mechanisms of long non-coding RNA in colorectal cancer

作者：Yuning Lin, Wenzhen Zhao, Zhenyi Lv, Xie Hongyan, Ying Li, Zhongying Zhang · 发表于：Frontiers in Oncology · 年份：2024 · DOI：10.3389/fonc.2024.1419972 · 被引用次数：8 · 研究领域：Cancer-related molecular mechanisms research、Mycobacterium research and diagnosis、RNA modifications and cancer

CRC poses a significant challenge in the global health domain, with a high number of deaths attributed to this disease annually. If CRC is detected only in its advanced stages, the difficulty of treatment increases significantly. Therefore, biomarkers for the early detection of CRC play a crucial role in improving patient outcomes and increasing survival rates. The development of a reliable biomarker for early detection of CRC is particularly important for timely diagnosis and treatment. However, current methods for CRC detection, such as endoscopic examination, blood, and stool tests, have certain limitations and often only detect cases in the late stages. To overcome these constraints, researchers have turned their attention to molecular biomarkers, which are considered a promising approach to improving CRC detection. Non-invasive methods using biomarkers such as mRNA, circulating cell-free DNA, microRNA, LncRNA, and proteins can provide more reliable diagnostic information. These biomarkers can be found in blood, tissue, stool, and volatile organic compounds. Identifying molecular biomarkers with high sensitivity and specificity for the early and safe, economic, and easily measurable detection of CRC remains a significant challenge for researchers.