FOXM1 transcriptional regulation

作者：Mengxi Li, Xuzheng Gao, Yanting Su, Shigang Shan, Wenbin Qian, Zhenwang Zhang, Dan Zhu · 发表于：Biology of the Cell · 年份：2024 · DOI：10.1111/boc.202400012 · 被引用次数：17 · 研究领域：FOXO transcription factor regulation、Pancreatic function and diabetes、Cancer Mechanisms and Therapy

FOXM1 is a key transcriptional regulator involved in various biological processes in mammals, including carbohydrate and lipid metabolism, aging, immune regulation, development, and disease. Early studies have shown that FOXM1 acts as an oncogene by regulating cell proliferation, cell cycle, migration, metastasis, and apoptosis, as well as genes related to diagnosis, treatment, chemotherapy resistance, and prognosis. Researchers are increasingly focusing on FOXM1 functions in tumor microenvironment, epigenetics, and immune infiltration. However, researchers have not comprehensively described FOXM1's involvement in tumor microenvironment shaping, epigenetics, and immune cell infiltration. Here we review the role of FOXM1 in the formation and development of malignant tumors, and we will provide a comprehensive summary of the role of FOXM1 in transcriptional regulation, interacting proteins, tumor microenvironment, epigenetics, and immune infiltration, and suggest areas for further research.