Evolution and host-specific adaptation ofPseudomonas aeruginosa

作者：Aaron Weimann, Adam M. Dinan, Christopher Ruis, Audrey Bernut, Stéphane Pont, Karen Brown, Judy Ryan, L. Santos, Louise Ellison, Emem Ukor, Arun Prasad Pandurangan, Sina Krokowski, Tom L. Blundell, Martin Welch, Beth Blane, Kim Judge, Rachel Bousfield, Nicholas M. Brown, Josephine M. Bryant, Irena Kukavica‐Ibrulj, Giordano Rampioni, Livia Leoni, Patrick T. Harrison, Sharon J. Peacock, Nicholas R. Thomson, Jeff Gauthier, Jo Fothergill, Roger C. Lévesque, Julian Parkhill, R. Andrés Floto · 发表于：Science · 年份：2024 · DOI：10.1126/science.adi0908 · 被引用次数：122 · 研究领域：Bacterial biofilms and quorum sensing、Antibiotic Resistance in Bacteria、Vibrio bacteria research studies

The major human bacterial pathogenPseudomonas aeruginosacauses multidrug-resistant infections in people with underlying immunodeficiencies or structural lung diseases such as cystic fibrosis (CF). We show that a few environmental isolates, driven by horizontal gene acquisition, have become dominant epidemic clones that have sequentially emerged and spread through global transmission networks over the past 200 years. These clones demonstrate varying intrinsic propensities for infecting CF or non-CF individuals (linked to specific transcriptional changes enabling survival within macrophages); have undergone multiple rounds of convergent, host-specific adaptation; and have eventually lost their ability to transmit between different patient groups. Our findings thus explain the pathogenic evolution ofP. aeruginosaand highlight the importance of global surveillance and cross-infection prevention in averting the emergence of future epidemic clones.