Prenatal PM2.5 Exposure Associated with Neonatal Gut Bacterial Colonization and Early Children’s Cognitive Development

作者：Yang Liu, Liyi Zhang, Jieming Wang, Xinyao Sui, Jiufeng Li, Yuyan Gui, Hang Wang, Yue Zhao, Yaqi Xu, Weizhao Cao, Pengpeng Wang, Yunhui Zhang · 发表于：Environment & Health · 年份：2024 · DOI：10.1021/envhealth.4c00050 · 被引用次数：16 · 研究领域：Air Quality and Health Impacts、Health, Environment, Cognitive Aging、Climate Change and Health Impacts

High Resolution Image Download MS PowerPoint Slide Previous research indicated that fine particulate matter (PM 2.5 ) exposure affected both offspring neurodevelopment and the colonization of gut microbiota (GM), while the underlying mechanism remained unclear. Our study aimed to evaluate the impacts of prenatal PM 2.5 exposure on child cognitive development and investigate the role of neonatal GM colonization in the association. Based on the Shanghai Maternal–Child Pairs Cohort, 361 maternal–child pairs were recruited. Prenatal PM 2.5 exposure concentrations were estimated using a high-spatial-resolution prediction model, and child neurodevelopment was assessed by the Ages and Stages Questionnaire. Multivariable linear regression models, logistic regression models, linear discriminant analysis effect size, and random forest model were applied to explore the associations among PM 2.5 exposure, GM colonization, and children’s neurodevelopment. The present study revealed a negative correlation between PM 2.5 exposure throughout pregnancy and child neurodevelopment. Prenatal PM 2.5 exposure was associated with an increased risk of suspected developmental delay (SDD) (OR = 1.683, 95% CI: 1.138, 2.489) in infants aged 2 months. Additionally, potential operational taxonomic unit markers were identified for PM 2.5 -related neurotoxicity, demonstrating promising classification potential for early SDD screening (AUC = 71.27%). Prenatal PM 2.5 exposure might disrupt the composition, ri...