Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery

作者：Yuan Li, Yingjie Li, Xu Fang, Dongqin Chen, Wan‐Qiu Yu, Zhaoqiong Zhu · 发表于：Frontiers in Cellular Neuroscience · 年份：2024 · DOI：10.3389/fncel.2024.1365448 · 被引用次数：13 · 研究领域：Anesthesia and Neurotoxicity Research、Intensive Care Unit Cognitive Disorders、Cancer, Stress, Anesthesia, and Immune Response

General anesthesia, as a commonly used medical intervention, has been widely applied during surgical procedures to ensure rapid loss of consciousness and pain relief for patients. However, recent research suggests that general anesthesia may be associated with the occurrence of perioperative neurocognitive disorder (PND). PND is characterized by a decline in cognitive function after surgery, including impairments in attention, memory, learning, and executive functions. With the increasing trend of population aging, the burden of PND on patients and society's health and economy is becoming more evident. Currently, the clinical consensus tends to believe that peripheral inflammation is involved in the pathogenesis of PND, providing strong support for further investigating the mechanisms and prevention of PND.