Inflammation as a therapeutic target for osteoarthritis: A literature review of clinical trials

作者：Rui Zhu, Haonan Fang, Junjie Wang, Liru Ge, Xiaoyue Zhang, Dawn Aitken, Guoqi Cai · 发表于：Clinical Rheumatology · 年份：2024 · DOI：10.1007/s10067-024-07042-y · 被引用次数：32 · 研究领域：Osteoarthritis Treatment and Mechanisms、Inflammatory mediators and NSAID effects、Rheumatoid Arthritis Research and Therapies

The burden of osteoarthritis (OA) is rapidly increasing with population aging, but there are still no approved disease-modifying drugs available. Accumulating evidence has shown that OA is a heterogeneous disease with multiple phenotypes, and it is unlikely to respond to one-size-fits-all treatments. Inflammation is recognized as an important phenotype of OA and is associated with worse pain and joint deterioration. Therefore, it is believed that anti-inflammatory treatments may be more effective for OA with an inflammatory phenotype. In this review, we summarized clinical trials that evaluated anti-inflammatory treatments for OA and discussed whether these treatments are more effective in inflammatory OA phenotypes compared to general OA patients.