Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU

作者：Yujie Cai, Jin Yao, Yingxuan Liu, Dandan Zhang, Zheng Gong, Li Li, Xiongjin Chen, Chunmei Liang, Sifan Feng, Jiongtong Lu, Qinjie Qiu, Zhixiong Lin, Yan Wang, Lili Cui · 发表于：Theranostics · 年份：2024 · DOI：10.7150/thno.96890 · 被引用次数：27 · 研究领域：Circular RNAs in diseases、MicroRNA in disease regulation、Nuclear Receptors and Signaling

The findings of the present study revealed that the expression of circUBE2K, which combines with HNRNPU to form the circUBE2K/HNRNPU complex, is increased in microglia after external stress, thus regulating the expression of the parental gene UBE2K and mediating the abnormal activation of microglia to induce neuroinflammation, promoting the development of MDD. These results indicate that circ-UBE2K plays a newly discovered role in the pathogenesis of depression.