Iron/Molybdenum Sulfide Nanozyme Cocatalytic Fenton Reaction for Photothermal/Chemodynamic Efficient Wound Healing

作者：Song Hui-ping, Zheng Cheng, Ran Qin, Ziyu Chen, Tianxiao Wang, Yuli Wang, Huijun Jiang, Yifei Du, Fan Wu · 发表于：Langmuir · 年份：2024 · DOI：10.1021/acs.langmuir.4c00922 · 被引用次数：21 · 研究领域：Advanced Nanomaterials in Catalysis、Advanced Photocatalysis Techniques、Nanoplatforms for cancer theranostics

The issue of bacterial infectious diseases remains a significant concern worldwide, particularly due to the misuse of antibiotics, which has caused the emergence of antibiotic-resistant strains. Fortunately, the rapid development of nanomaterials has propelled significant progress in antimicrobial therapy, offering promising solutions. Among them, the utilization of nanoenzyme-based chemodynamic therapy (CDT) has become a highly hopeful approach to combating bacterial infectious diseases. Nevertheless, the application of CDT appears to be facing certain constraints for its low efficiency in the Fenton reaction at the infected site. In this study, we have successfully synthesized a versatile nanozyme, which was a composite of molybdenum sulfide (MoS 2 ) and iron sulfide (FeS 2 ), through the hydrothermal method. The results showed that iron/molybdenum sulfide nanozymes (Fe/Mo SNZs) with desirable peroxidase (POD) mimic activity can generate cytotoxic reactive oxygen species (ROS) by successfully triggering the Fenton reaction. The presence of MoS 2 significantly accelerates the conversion of Fe 2+ /Fe 3+ through a cocatalytic reaction that involves the participation of redox pairs of Mo 4+ /Mo 6+, thereby enhancing the efficiency of CDT. Additionally, based on the excellent photothermal performance of Fe/Mo SNZs, a near-infrared (NIR) laser was used to induce localized temperature elevation for photothermal therapy (PTT) and enhance the POD-like nanoenzymatic activity. Notably...