Concise synthesis of chiral γ-butenolides via an allylation/lactonization cascade reaction

作者：Zheng Tan, Aying Yihuo, Zhao Wu, Fei Wang, Shunxi Dong, Xiaoming Feng · 发表于：Chemical Communications · 年份：2024 · DOI：10.1039/d4cc02781g · 被引用次数：8 · 研究领域：Synthetic Organic Chemistry Methods、Asymmetric Synthesis and Catalysis、Synthesis and pharmacology of benzodiazepine derivatives

A highly enantioselective allylation/lactonization cascade was developed, which provides a concise and efficient route to chiral γ-butenolides under mild conditions. Most of the reaction examples can be completed in 10 minutes with high selectivity.