BDNF-loaded chitosan-based mimetic mussel polymer conduits for repair of peripheral nerve injury

作者：Lei Li, Ziyue Chu, Shihao Li, Tong Zheng, Shusheng Wei, Yunpeng Zhao, Peilai Liu, Qunshan Lu · 发表于：Frontiers in Cell and Developmental Biology · 年份：2024 · DOI：10.3389/fcell.2024.1431558 · 被引用次数：8 · 研究领域：Nerve injury and regeneration、Electrospun Nanofibers in Biomedical Applications、Nerve Injury and Rehabilitation

Care for patients with peripheral nerve injury is multifaceted, as traditional methods are not devoid of limitations. Although the utilization of neural conduits shows promise as a therapeutic modality for peripheral nerve injury, its efficacy as a standalone intervention is limited. Hence, there is a pressing need to investigate a composite multifunctional neural conduit as an alternative treatment for peripheral nerve injury. In this study, a BDNF-loaded chitosan-based mimetic mussel polymer conduit was prepared. Its unique adhesion characteristics allow it to be suture-free, improve the microenvironment of the injury site, and have good antibacterial properties. Researchers utilized a rat sciatic nerve injury model to evaluate the progression of nerve regeneration at the 12-week postoperative stage. The findings of this study indicate that the chitosan-based mimetic mussel polymer conduit loaded with BDNF had a substantial positive effect on myelination and axon outgrowth. The observed impact demonstrated a favorable outcome in terms of sciatic nerve regeneration and subsequent functional restoration in rats with a 15-mm gap. Hence, this approach is promising for nerve tissue regeneration during peripheral nerve injury.