Molecular mechanisms of diabetic nephropathy: A narrative review

作者：Tian Sun, Yina Guo, Yanting Su, Shigang Shan, Wenbin Qian, Feixue Zhang, Mengxi Li, Zhenwang Zhang · 发表于：Cell Biology International · 年份：2024 · DOI：10.1002/cbin.12212 · 被引用次数：11 · 研究领域：Chronic Kidney Disease and Diabetes、Advanced Glycation End Products research、Diet, Metabolism, and Disease

Diabetic nephropathy (DN) is the predominant secondary nephropathy resulting in global end-stage renal disease. It is attracting significant attention in both domestic and international research due to its widespread occurrence, fast advancement, and limited choices for prevention and treatment. The pathophysiology of this condition is intricate and involves multiple molecular and cellular pathways at various levels. This article provides a concise overview of the molecular processes involved in the development of DN. It discusses various factors, such as signaling pathways, cytokines, inflammatory responses, oxidative stress, cellular damage, autophagy, and epigenetics. The aim is to offer clinicians a valuable reference for DN's diagnosis, treatment, and intervention.