Circulating Tumor DNA Predicts Early Recurrence Following Locoregional Therapy for Oligometastatic Colorectal Cancer

作者：C. O'Donnell, Nikolas Naleid, Teerada Siripoon, Kevin Zablonski, Michael H. Storandt, J. Eva Selfridge, Christopher L. Hallemeier, Madison Conces, Krishan R. Jethwa, David L. Bajor, Cornelius A. Thiels, Susanne G. Warner, Patrick Starlinger, Thomas D. Atwell, Jessica L. Mitchell, Amit Mahipal, Zhaohui Jin · 发表于：Cancers · 年份：2024 · DOI：10.3390/cancers16132407 · 被引用次数：4 · 研究领域：Cancer Genomics and Diagnostics、Genetic factors in colorectal cancer、Cancer Cells and Metastasis

(1) Background: Local therapies offer a potentially curative approach for patients with oligometastatic colorectal cancer (CRC). An evidence-based consensus recommendation for systemic therapy following definitive locoregional therapy is lacking. Tumor-informed circulating tumor DNA (ctDNA) might provide information to help guide management in this setting. (2) Methods: A multi-institutional retrospective study was conducted, including patients with CRC that underwent curative-intent locoregional therapy to an isolated site of metastatic disease, followed by tumor-informed ctDNA assessment. The Kaplan–Meier method and log-rank tests were used to compare disease-free survival based on ctDNA results. ctDNA test performance was compared to carcinoembryonic antigen (CEA) test results using McNemar’s test. (3) Results: Our study cohort consisted of 87 patients treated with locoregional interventions who underwent ctDNA testing. The initial ctDNA test post-intervention was positive in 28 patients and negative in 59 patients. The median follow-up time was 14.0 months. Detectable ctDNA post-intervention was significantly associated with early disease recurrence, with a median disease-free survival (DFS) of 6.63 months compared to 21.30 months in ctDNA-negative patients (p < 0.001). ctDNA detected a numerically higher proportion of recurrences than CEA (p < 0.097). Post-intervention systemic therapy was not associated with improved DFS (p = 0.745). (4) Conclusions: ctDNA results...