Helping ourselves, helping others: the Young Women’s Breast Cancer Study (YWS) – a multisite prospective cohort study to advance the understanding of breast cancer diagnosed in women aged 40 years and younger

作者：Shoshana M. Rosenberg, Yue Hong Zheng, Kathryn J. Ruddy, Philip Daniel Poorvu, Craig Snow, Gregory John Kirkner, Meghan E. Meyer, Rulla M. Tamimi, Lidia Schapira, Jeffrey M. Peppercorn, Steven E. Come, Virginia F. Borges, Ellen Warner, Shari I. Gelber, Laura C. Collins, Eric P. Winer, Ann H. Partridge · 发表于：BMJ Open · 年份：2024 · DOI：10.1136/bmjopen-2023-081157 · 被引用次数：18 · 研究领域：Cancer Risks and Factors、Reproductive Biology and Fertility、Breast Cancer Treatment Studies

PURPOSE: Compared with older women diagnosed with breast cancer, younger women are more likely to die of breast cancer and more likely to suffer psychosocially in both the short-term and long term. The Young Women's Breast Cancer Study (YWS) is a multisite prospective cohort study established to address gaps in our knowledge about this vulnerable and understudied population. PARTICIPANTS: The YWS enrolled 1302 women newly diagnosed with stages 0-IV breast cancer at age 40 years or younger at 13 academic and community sites in North America between 2006 and 2016. Longitudinal patient-reported outcome data are complemented by clinical data abstraction and biospecimen collection at multiple timepoints. FINDINGS TO DATE: Key findings related to fertility include that nearly 40% of participants were interested in pregnancy following diagnosis; of those who reported interest, 10% pursued fertility preservation. Overall, approximately 10% of YWS participants became pregnant in the first 5 years after diagnosis; follow-up is ongoing for pregnancies after 5 years. Studies focused on psychosocial outcomes have characterised quality of life, post-traumatic stress and fear of recurrence, with findings detailing the factors associated with the substantial psychosocial burden many young women face during and following active treatment. Multiple studies have leveraged YWS biospecimens, including whole-exome sequencing of tumour analyses that revealed that select somatic alterations occur at...