Immunomodulating Sonocatalytic Nanoagents with Dual‐Functional Ir‐N Centers and Narrow Bandgap for Reversing Immunosuppression and Potentiating Ovarian Cancer Immunotherapy

作者：Xiaotong Huang, Hongju Zhou, Ning Lv, Zhenyang Zhao, Tian Tian, Jiayan Huang, Raúl D. Rodriguez, Hong Jie Luo, Chong Cheng, Lang Ma · 发表于：Advanced Functional Materials · 年份：2024 · DOI：10.1002/adfm.202407349 · 被引用次数：19 · 研究领域：Nanoplatforms for cancer theranostics、Ultrasound and Hyperthermia Applications、Anesthesia and Neurotoxicity Research

Abstract The heterogeneity and immunosuppression microenvironment of ovarian cancer seriously restrict the efficiency of monomodal treatment. Emerging multimodal therapy strategies based on sonodynamic therapy with enhanced antitumor effects have attracted intensive attention in the quest to combat cancer. However, exploring highly efficient sonosensitizers integrating chemodynamic/sonodynamic/immunotherapies with reversing immunosuppressive tumor microenvironment (TME) capacity is urgently desired but remains challenging. Here, a facile strategy is designed to synthesize immunomodulating sonocatalytic nanoagents (IrT‐SCN) with dual‐functional Ir‐N centers and narrow bandgap for reversing immunosuppression and potentiating ovarian cancer immunotherapy. IrT‐SCN with dual‐functional centers Ir‐N 2 and Ir‐N 4 and conjugated networks show a reduced bandgap, moderate interaction with H 2 O 2 , and efficient production of reactive oxygen species (ROS). Such ROS capabilities include: 1) utilizing H 2 O 2 in TME to catalytically generate potent O 2 , as well as abundant superoxide anion (•O 2 − ) and singlet oxygen ( 1 O 2 ) radicals; 2) external ultrasound (US) irradiation can also boost the production of 1 O 2 simultaneously; 3) M1 polarization of tumor‐associated macrophages and enhanced immune effect can promote the outcome of cancer treatment. This finding provides proof‐of‐concept evidence for the future development of immunomodulating sonocatalytic nanoagents for oncological t...