Antinephrin-Associated Primary Focal Segmental Glomerulosclerosis Successfully Treated With Plasmapheresis

作者：Iain Bressendorff, Karl Emil Nelveg-Kristensen, Maryam Ghasemi, Andrew Watts, Johanna Elversang, Keith Keller, Finn Cilius Nielsen, Wladimir Szpirt, Astrid Weins · 发表于：Kidney International Reports · 年份：2024 · DOI：10.1016/j.ekir.2024.06.038 · 被引用次数：7 · 研究领域：Renal Diseases and Glomerulopathies、Amyloidosis: Diagnosis, Treatment, Outcomes、Complement system in diseases

Minimal change disease and primary focal segmental glomerulosclerosis (FSGS) have similar clinical manifestations, both presenting with rapid-onset nephrotic syndrome and often amendable to treatment with high-dose glucocorticoids. Recently, antinephrin antibodies (Ab) have been reported to be present in a subset of patients with minimal change disease as well as in patients with primary FSGS with recurrent massive proteinuria after kidney transplantation.1-3 Infusion of antinephrin Ab in mice results in rapid-onset proteinuria and subsequent FSGS lesions.