Mimicking Mytilus edulis foot protein: A versatile strategy for robust biomedical coatings

作者：Zeyu Du, Feng Qiao, Liping Tong, Wentai Zhang, Xiaohui Mou, Xin Zhao, Manfred F. Maitz, Huaiyu Wang, Nan Huang, Zhilu Yang · 发表于：The Innovation · 年份：2024 · DOI：10.1016/j.xinn.2024.100671 · 被引用次数：34 · 研究领域：Polymer Surface Interaction Studies、Electrospun Nanofibers in Biomedical Applications、Advanced Sensor and Energy Harvesting Materials

Universal coatings with versatile surface adhesion, good mechanochemical robustness, and the capacity for secondary modification are of great scientific interest. However, incorporating these advantages into a system is still a great challenge. Here, we report a series of catechol-decorated polyallylamines (CPAs), denoted as pseudo- Mytilus edulis foot protein 5 ( pseudo -Mefp-5), that mimic not only the catechol and amine groups but also the backbone of Mefp-5. CPAs can fabricate highly adhesive, robust, multifunctional polyCPA (PCPA) coatings based on synergetic catechol-polyamine chemistry as universal building blocks. Due to the interpenetrating entangled network architectures, these coatings exhibit high chemical robustness against harsh conditions (HCl, pH 1; NaOH, pH 14; H 2 O 2 , 30%), good mechanical robustness, and wear resistance. In addition, PCPA coatings provide abundant grafting sites, enabling the fabrication of various functional surfaces through secondary modification. Furthermore, the versatility, multifaceted robustness, and scalability of PCPA coatings indicate their great potential for surface engineering, especially for withstanding harsh conditions in multipurpose biomedical applications.