Iodine Mediated Annulation of Triethylamine, Aldehydes and 2‐Aminopyridines for the Synthesis of 3‐Formyl‐Imidazo [1,2‐a]pyridine Derivatives

作者：Wenqing Zhang, Lihong Shen, Jun Zhang · 发表于：Advanced Synthesis & Catalysis · 年份：2024 · DOI：10.1002/adsc.202400473 · 被引用次数：12 · 研究领域：Synthesis and Biological Evaluation、Quinazolinone synthesis and applications、Synthesis and bioactivity of alkaloids

Abstract With triethylamine as a synthon, an alternative method for the synthesis of 3‐formyl imidazo[1,2‐a]pyridines has been accomplished from aldehydes, and 2‐aminopyridines. The reaction proceeded via iodine‐catalyzed C−N bond cleavage of triethylamine, generation of α , β ‐unsaturated aldehyde in situ, and oxidative cyclization with air as the oxygen source. This protocol may facilitate the synthesis of imidazo[1,2‐a]pyridine derivatives and provide a reference for the usage of triethylamine as a synthon.