Formate and CO 2 Enable Reductive Carboxylation of Imines: Synthesis of Unnatural α-Amino Acids

作者：Pei Xu, Wenwen Liu, Tian-Zi Hao, Yiqin Liu, Hui-Xian Jiang, Jing Xu, Jin-You Li, Long Yin, Songlei Zhu, Xu Zhu · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.3c02887 · 被引用次数：20 · 研究领域：Carbon dioxide utilization in catalysis、Asymmetric Hydrogenation and Catalysis、CO2 Reduction Techniques and Catalysts

Herein, a photocatalytic umpolung strategy for reductive carboxylation of imines for the synthesis of α-amino acids was disclosed. Carbon dioxide radical anion (CO 2 •– ) generated from formate is the key single electron reductant in the reactions. An unprecedentedly broad substrate scope of imines with excellent reaction yields was obtained with carbon dioxide (CO 2 ) and formate salt as carbon sources.