Inflammatory markers and body mass index amoung hispanic children

作者：Henry T. Lang, Elaine Loudermilk, William Clark, Jo‐Ann Marrs, T. Andrew Joyner, Liang Wang, Kathryn S. Gerber, Arsham Alamian · 发表于：PLoS ONE · 年份：2024 · DOI：10.1371/journal.pone.0289523 · 被引用次数：5 · 研究领域：Adipokines, Inflammation, and Metabolic Diseases、Obesity, Physical Activity, Diet、Biomarkers in Disease Mechanisms

BACKGROUND AND OBJECTIVES: Body mass index (BMI) is inversely proportional with adiponectin levels among adults, while insulin, C-reactive protein (CRP), interleukin 6 (IL-6), resistin and tumor necrosis factor-alpha (TNF-α) have been linked with elevated BMI. The role and relation of these biomarkers with BMI among a Hispanic pediatric population are less known. Thus, the objective of this study was to examine the association of inflammatory markers with the odds of overweight/obesity while controlling for several sociodemographic factors among a Hispanic youth population in Northeast Tennessee. METHODS: Height, weight, demographic information, and blood samples were collected from 107 Hispanic children aged 2 to 10 years recruited at a large community health center in 2015-2016 in Northeast Tennessee. Data for this research were accessed and analyzed in 2022. Multivariable logistic regression was conducted to assess the relations between adiponectin, insulin, resistin, CRP, TNF-α, and IL-6, and overweight/obesity vs. having a healthy (normal) weight. RESULTS: Adiponectin levels were significantly lower among overweight/obese Hispanic children (p = 0.0144) compared to healthy weight children. The odds of overweight/obesity decreased by 4% for every one-unit increase in serum adiponectin. Insulin levels were significantly higher among overweight/obese Hispanic children compared to healthy weight children (p = 0.0048). The odds of overweight/obesity increased by 7% for every o...