Advances in bacteria‐based drug delivery systems for anti‐tumor therapy

作者：Shuwen Han, Song Yifei, Xinyue Wu, Qu Zhanbo, Yu Xiang, Xi Yang · 发表于：Clinical & Translational Immunology · 年份：2024 · DOI：10.1002/cti2.1518 · 被引用次数：28 · 研究领域：Cancer Research and Treatments、Bacteriophages and microbial interactions、Nanoplatforms for cancer theranostics

In recent years, bacteria have gained considerable attention as a promising drug carrier that is critical in improving the effectiveness and reducing the side effects of anti-tumor drugs. Drug carriers can be utilised in various forms, including magnetotactic bacteria, bacterial biohybrids, minicells, bacterial ghosts and bacterial spores. Additionally, functionalised and engineered bacteria obtained through gene engineering and surface modification could provide enhanced capabilities for drug delivery. This review summarises the current studies on bacteria-based drug delivery systems for anti-tumor therapy and discusses the prospects and challenges of bacteria as drug carriers. Furthermore, our findings aim to provide new directions and guidance for the research on bacteria-based drug systems.