Association between Hematocrit and Acute Kidney Injury in Patients with Acute Myocardial Infarction

作者：Sheng Su, Likun Zhou, Le Li, Zhuxin Zhang, Yulong Xiong, Zhenghao Zhang, Zhao Hu, Yan Yao · 发表于：Reviews in Cardiovascular Medicine · 年份：2024 · DOI：10.31083/j.rcm2506228 · 被引用次数：4 · 研究领域：Blood properties and coagulation、Acute Kidney Injury Research、Erythropoietin and Anemia Treatment

Backgrounds: Hematocrit is found an independent risk factor for acute kidney injury (AKI) in certain patients, but this effect in patients with acute myocardial infarction (AMI) is unclear. We aim to identify the relationship between hematocrit and AKI in patients with AMI. Methods: The patient data for the discovery and validation cohorts were extracted from the electronic Intensive Care Unit database and the Medical Information Mart for Intensive Care III database, respectively, to identify the relationship between hematocrit and AKI. With normal hematocrit as the reference, patients were divided into five groups based on the initial hematocrit value. The primary outcome was AKI during hospitalization. A multivariable logistic regression and a marginal effect analysis were used to evaluate the relationship between hematocrit and AKI. Results: In this study, a total of 9692 patients diagnosed with AMI were included, with 7712 patients in the discovery cohort and 1980 patients in the validation cohort. In the discovery cohort, hematocrit in 30–33%, 27–30% or <27% were independent risk factors for AKI in the multivariate logistic analysis, with odds ratio (OR) of 1.774 (95% confidence interval [CI]: 1.203–2.617, p = 0.004), 1.834 (95% CI: 1.136–2.961, p = 0.013) and 2.577 (95% CI: 1.510–4.397, p < 0.001), respectively. Additionally, in the validation cohort, low hematocrit levels independently contributed to an increased risk of AKI among patients with AMI. During the an...