Identification of the serum metabolites associated with cow milk consumption in Chinese Peri-/Postmenopausal women

作者：Bo Tian, Lulu Xu, Lindong Jiang, Lin Xu, Jie Shen, Hui Shen, Kuan‐Jui Su, Rui Gong, Chuan Qiu, Zhe Luo, Jia-Heng Yao, Zhuo-Qi Wang, Hongmei Xiao, Li-Shu Zhang, Hong‐Wen Deng · 发表于：International Journal of Food Sciences and Nutrition · 年份：2024 · DOI：10.1080/09637486.2024.2366223 · 被引用次数：3 · 研究领域：Phytoestrogen effects and research、Gut microbiota and health、Fatty Acid Research and Health

Cow milk consumption (CMC) and downstream alterations of serum metabolites are commonly considered important factors regulating human health status. Foods may lead to metabolic changes directly or indirectly through remodelling gut microbiota (GM). We sought to identify the metabolic alterations in Chinese Peri-/Postmenopausal women with habitual CMC and explore if the GM mediates the CMC-metabolite associations. 346 Chinese Peri-/Postmenopausal women participants were recruited in this study. Fixed effects regression and partial least squares discriminant analysis (PLS-DA) were applied to reveal alterations of serum metabolic features in different CMC groups. Spearman correlation coefficient was computed to detect metabolome-metagenome association. 36 CMC-associated metabolites including palmitic acid (FA(16:0)), 7alpha-hydroxy-4-cholesterin-3-one (7alphaC4), citrulline were identified by both fixed effects regression (FDR < 0.05) and PLS-DA (VIP score > 2). Some significant metabolite-GM associations were observed, including FA(16:0) with gut species Bacteroides ovatus, Bacteroides sp.D2. These findings would further prompt our understanding of the effect of cow milk on human health.