The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review

作者：Kai Wang, Kai Wang, Cuiyun Liu, Bo Fang, Bo Li, Yinghui Li, Qian-Qian Xia, Yan Zhao, Xueli Cheng, Sumin Yang, Meihua Zhang, Kun Wang, Kun Wang · 发表于：Pharmacological Research · 年份：2024 · DOI：10.1016/j.phrs.2024.107279 · 被引用次数：16 · 研究领域：RNA modifications and cancer、Cancer-related molecular mechanisms research、RNA and protein synthesis mechanisms

Transfer RNA-derived small RNAs (tsRNAs) are a class of small non-coding RNA (sncRNA) molecules derived from tRNA, including tRNA derived fragments (tRFs) and tRNA halfs (tiRNAs). tsRNAs can affect cell functions by participating in gene expression regulation, translation regulation, intercellular signal transduction, and immune response. They have been shown to play an important role in various human diseases, including cardiovascular diseases (CVDs). Targeted regulation of tsRNAs expression can affect the progression of CVDs. The tsRNAs induced by pathological conditions can be detected when released into the extracellular, giving them enormous potential as disease biomarkers. Here, we review the biogenesis, degradation process and related functional mechanisms of tsRNAs, and discuss the research progress and application prospects of tsRNAs in different CVDs, to provide a new perspective on the treatment of CVDs.