Common Biosynthesis of Non‐Canonical C 16 Terpenes through a Fragmentation‐Recombination Mechanism

作者：Houchao Xu, Bernd Goldfuß, Jeroen S. Dickschat · 发表于：Angewandte Chemie International Edition · 年份：2024 · DOI：10.1002/anie.202408809 · 被引用次数：16 · 研究领域：Plant biochemistry and biosynthesis、Microbial Natural Products and Biosynthesis、Natural product bioactivities and synthesis

sesquiterpenoids named after ancient Greek philosophers, archimedene, aristotelene, eratosthenene, pythagorene, α-democritene and anaximandrene, was investigated through density functional theory (DFT) calculations and isotopic labeling experiments. The results revealed for all compounds except archimedene a unique fragmentation-recombination mechanism as previously demonstrated for sodorifen biosynthesis, in addition to a remarkable "dancing" mechanism for anaximandrene biosynthesis.