Examining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study

作者：Emily W. Paolillo, Kaitlin B. Casaletto, Annie L Clark, Jack C. Taylor, Hilary W. Heuer, Amy B. Wise, Sreya Dhanam, Mark Sanderson‐Cimino, Rowan Saloner, Joel H. Kramer, John Kornak, Walter K. Kremers, Leah K. Forsberg, Brian S. Appleby, Ece Bayram, Andrea Bozoki, Danielle Brushaber, R. Ryan Darby, Gregory S. Day, Bradford C. Dickerson, Kimiko Domoto‐Reilly, Fanny M. Elahi, Julie A. Fields, Nupur Ghoshal, Neill R. Graff‐Radford, Matthew Hall, Lawrence S. Honig, Edward D. Huey, Maria I. Lapid, Irene Litvan, Ian R. Mackenzie, Joseph C. Masdeu, Mario F. Mendez, Carly Mester, Toji Miyagawa, Georges Naasan, Belén Pascual, Peter Pressman, Eliana Marisa Ramos, Katherine P. Rankin, Jessica E. Rexach, Julio C. Rojas, Lawren VandeVrede, Bonnie Wong, Zbigniew K. Wszołek, Bradley F. Boeve, Howard J. Rosen, Adam L. Boxer, Adam M. Staffaroni · 发表于：JMIR Aging · 年份：2024 · DOI：10.2196/52831 · 被引用次数：11 · 研究领域：Dementia and Cognitive Impairment Research、Older Adults Driving Studies、Technology Use by Older Adults

BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a leading cause of dementia in individuals aged <65 years. Several challenges to conducting in-person evaluations in FTLD illustrate an urgent need to develop remote, accessible, and low-burden assessment techniques. Studies of unobtrusive monitoring of at-home computer use in older adults with mild cognitive impairment show that declining function is reflected in reduced computer use; however, associations with smartphone use are unknown. OBJECTIVE: This study aims to characterize daily trajectories in smartphone battery use, a proxy for smartphone use, and examine relationships with clinical indicators of severity in FTLD. METHODS: Participants were 231 adults (mean age 52.5, SD 14.9 years; n=94, 40.7% men; n=223, 96.5% non-Hispanic White) enrolled in the Advancing Research and Treatment of Frontotemporal Lobar Degeneration (ARTFL study) and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS study) Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Mobile App study, including 49 (21.2%) with mild neurobehavioral changes and no functional impairment (ie, prodromal FTLD), 43 (18.6%) with neurobehavioral changes and functional impairment (ie, symptomatic FTLD), and 139 (60.2%) clinically normal adults, of whom 55 (39.6%) harbored heterozygous pathogenic or likely pathogenic variants in an autosomal dominant FTLD gene. Participants completed the Clinical Dementia Rating plus National Alzheim...