Comparison of Hepatitis B Virus Infection in HIV-Infected and HIV-Uninfected Participants Enrolled in a Multinational Clinical Trial: HPTN 052

作者：Elizabeth Wilson, San‐San Ou, R. Panchia, S. Badal-Faesen, M. Nyirenda, J.H. Pilotto, Chloe L. Thio, Y.Q. Chen, Alexandra Valsamakis, Natthapol Kosashunhanan, Michael Forman, E. Piwowar-Manning, T. Gamble, M. McCauley, J. Makhema, M.G. De Melo, Cholticha Ruangyuttikarn, M.S. Cohen, S.H. Eshleman, Allen E. Greer, N. Kumarasamy, M.C. Hosseinipour, B. Grinsztejn, V. Akelo · 发表于：UNC Libraries · 年份：2023 · DOI：10.17615/36vv-pp55 · 研究领域：Hepatitis B Virus Studies、Hepatitis C virus research、HIV/AIDS Research and Interventions

Objective: Data comparing hepatitis B virus (HBV) infection in HIV-infected [HIV(+)], and HIV-uninfected [HIV(2)] individuals recruited into the same study are limited. HBV infection status and chronic hepatitis B (cHB) were characterized in a multinational clinical trial: HIV Prevention Trials Network (HPTN 052). Method: HBV infection status at enrollment was compared between HIV(+) (N = 1241) and HIV(-) (N = 1232) from 7 HBV-endemic countries. Hepatitis B e antigen and plasma HBV DNA were determined in cHB. Median CD4, median plasma HIV RNA, and prevalence of transaminase elevation were compared in HIV(+) with and without cHB. Significance was assessed with x2 Fisher exact and median tests. Results: Among all participants, 33.6% had HBV exposure without cHB (8.9% isolated HBV core antibody, "HBcAb"; 24.7% HBcAb and anti-HB surface antibody positive, "recovered"), 4.3% had cHB, 8.9% were vaccinated, and 53.5% were uninfected. Data were similar among HIV(+) and HIV(2) except for isolated HBcAb, which was more prevalent in HIV(+) than HIV(2) [10.1% vs. 7.7%, P = 0.046]. Median HBV DNA trended higher in HIV(+) than in HIV(2). In HIV (+) with cHB versus those without cHB, transaminase elevations were more prevalent (alanine aminotransferase # grade 2, 12% vs. 5.2%, P = 0.037; aspartate aminotransferase # grade 2, 26% vs. 6.0%, P, 0.001), CD4 trended lower, and HIV RNA was similar. Conclusions: HBV infection status did not differ by HIV infection status. HIV co-infection was asso...