Organocatalytic Enantioselective Chloroiminocyclization for the Synthesis of Imidazoline

作者：Qifeng Guo, Zhitao Lai, Tian Zeng, Ran Tang, Tengbo Ding, Xiaojian Jiang · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c02057 · 被引用次数：2 · 研究领域：Vanadium and Halogenation Chemistry、Chemical Synthesis and Reactions、Sulfur-Based Synthesis Techniques

Imidazoline is an important scaffold in organic synthesis and a pharmacophore in medicinal chemistry. We apply basic imines as nucleophiles for the catalytic asymmetric chloroiminocyclization to furnish tetrasubstituted stereocenter-containing imidazolines in excellent yields and enantioselectivities. The reaction can be conducted in the polar solvent acetonitrile under concentrated reaction conditions.