Non-mydriatic ultra-widefield diffraction-limited retinal imaging

作者：Shuibin Ni, Ringo Ng, David Huang, Siyu Chen, Benjamin K. Young, J. Peter Campbell, Yifan Jian · 发表于：Optics Letters · 年份：2024 · DOI：10.1364/ol.525364 · 被引用次数：6 · 研究领域：Optical Coherence Tomography Applications、Intraocular Surgery and Lenses、Glaucoma and retinal disorders

We demonstrate a new non-mydriatic ultra-widefield optical coherence tomography retinal imaging system, designed with custom optics to improve the imaging field of view, lateral resolution, and patient comfort. The key motivation is to address the challenge with conventional systems that require pupillary dilation, adding time, expense, discomfort, and medical risk to the examination of the retina. Our system provides an ultrawide 100° field of view (beam scanning angle at the scanning pivot point) and maintains a lateral resolution of 20 µm on the center. It also allows a generous working distance of 16 mm, 2-3 times longer than existing ultra-widefield OCT imaging systems. This advanced system was able to avoid iris vignetting artifacts without pharmacological dilation and ensure diffraction-limited ultra-widefield imaging under a generalized eye model. This enables a comprehensive evaluation of retina diseases, especially those affecting the peripheral regions.