Research on the correlation between rash and complement C3, C4 levels and the occurrence and development of lupus nephritis

作者：Fei Luo, Yongkang Chen, Jingzhi Xie, Yanzhen Zeng, Jingwen Wei, Runzhi Liu, Hanqiu Yin, Songlou Yin, Lili Duan, Dongmei Zhou · 发表于：Research Square · 年份：2024 · DOI：10.21203/rs.3.rs-4516028/v1 · 研究领域：Systemic Lupus Erythematosus Research、Atherosclerosis and Cardiovascular Diseases、Complement system in diseases

Abstract Objective We here investigate the relationship between the appearance of skin rash, complement, and the risk of systemic lupus erythematosus and lupus nephritis. Methods All data were collected from 71 patients with SLE (without LN) and 200 patients with LN treated at our hospital from August 2018 to August 2023. The latter group was further categorized into a high eGFR group (eGFR ≥ 60 ml/min; 100 cases) and a low eGFR group (eGFR < 60 ml/min; 100 cases). Basic clinical characteristics such as gender, age, fever, joint pain, rash, hair loss, along with laboratory indicators including cystatin C, complement C3, complement C4, and anti-dsDNA titers were gathered. The differences in clinical characteristics and hematological indicators between the SLE group and the LN group, as well as between the high eGFR group and the low eGFR group patients, were compared. Binary logistic regression analysis was employed to identify independent risk factors for the progression from SLE to LN and independent risk factors for the deterioration of renal function in LN. Correlation studies were conducted to elucidate the relationship between independent factors and the disease. The predictive value of risk was assessed using ROC curves. Results Compared to the SLE group, the absence of skin rash and low complement C3 levels were significantly associated with the occurrence of LN. Multifactor analysis revealed that both skin rash (OR: 0.231, P < 0.001) and complement C3 (OR: 0.08...