Lysosome-targeted cyclometalated Ir( iii ) complexes as photosensitizers/photoredox catalysts for cancer therapy

作者：Yu Chen, Chao Liang, Manchang Kou, Xiaoliang Tang, Jiaxi Ru · 发表于：Dalton Transactions · 年份：2024 · DOI：10.1039/d4dt01345j · 被引用次数：20 · 研究领域：Advanced Nanomaterials in Catalysis、Nanocluster Synthesis and Applications、Advanced biosensing and bioanalysis techniques

) and photocatalytically oxidize 1,4-dihydronicotinamide adenine dinucleotide (NADH) under light irradiation. Most importantly, the aforementioned activities are significantly enhanced due to protonation under acidic conditions, which makes them highly attractive in light-activated tumor therapy, especially for acidic lysosomes and tumor microenvironments. The photocytotoxicity of IrL and the mechanism of cell death have been investigated. Additionally, the tumor-killing ability of IrL under light irradiation was evaluated using a 4T1 tumor-bearing mouse model. This work provides a strategy for the development of lysosome-targeted photosensitizers/photoredox catalysts to overcome hypoxic tumors.