Mycobacterium tuberculosis infection induces a novel type of cell death: Ferroptosis

作者：Jianjun Wang, Hui Cao, Yiping Xie, Zi Xu, Yujie Li, Hao Luo · 发表于：Biomedicine & Pharmacotherapy · 年份：2024 · DOI：10.1016/j.biopha.2024.117030 · 被引用次数：17 · 研究领域：Ferroptosis and cancer prognosis、RNA modifications and cancer、Cancer, Lipids, and Metabolism

Ferroptosis is a lipid peroxidation-driven and iron-dependent form of programmed cell death, which is involved in a variety of physical processes and multiple diseases. Numerous reports have demonstrated that ferroptosis is closely related to the pathophysiological processes of Mycobacterium tuberculosis (M. tuberculosis) infection and is characterized by the accumulation of excess lipid peroxides on the cell membrane. In this study, the various functions of ferroptosis, and the therapeutic strategies and diagnostic biomarkers of tuberculosis, were summarized. Notably, this review provides insights into the molecular mechanisms and functions of M. tuberculosis-induced ferroptosis, suggesting potential future therapeutic and diagnostic markers for tuberculosis.