Cover Feature: sAPPα Peptide Promotes Damaged Microglia to Clear Alzheimer's Amyloid‐β via Restoring Mitochondrial Function (Chem. Eur. J. 40/2024)

作者：Yingqi Tang, Yangang Wang, Ziran Gao, Jiayi Li, Lijia Zhang, Haoting Shi, Jingwen Dong, Shipeng Song, Chenggen Qian · 发表于：Chemistry - A European Journal · 年份：2024 · DOI：10.1002/chem.202402238 · 研究领域：Alzheimer's disease research and treatments、Signaling Pathways in Disease、Genetics and Neurodevelopmental Disorders

The function of microglia to clear amyloid β (Aβ) is critical for Alzheimer′s patients. In their Research Article (DOI: 10.1002/chem.202400870), C. Qian and co-workers show how the soluble amyloid precursor protein α (sAPPα) effectively enhances phagocytosis and metabolism of Aβ in damaged microglia by restoring mitochondrial function. sAPPα exhibits promising potential as a safe therapeutic agent or drug carrier for the treatment of Alzheimer′s disease. Cover created by Yingqi Tang.