Identification of inflammatory markers as indicators for disease progression in primary Sjögren syndrome

作者：Yan Li, Jimin Zhang, Xiaoyan Liu, Kumar Ganesan, Guixiu Shi · 发表于：European Cytokine Network · 年份：2024 · DOI：10.1684/ecn.2024.0496 · 被引用次数：5 · 研究领域：Salivary Gland Disorders and Functions、Inflammasome and immune disorders、Thyroid Disorders and Treatments

Primary Sjögren syndrome (pSS) is a systemic autoimmune disorder that affects various systems in the body, resulting in symptoms such as dry eyes and mouth, pain, and fatigue. Inflammation plays a critical role in pSS and its associated complications, with chronic inflammation being a common occurrence in patients with pSS. This review of the literature highlights inflammatory markers that could serve as indicators to predict disease progression in pSS. Laboratory markers are frequently and significantly increased in pSS patients, including erythrocyte sedimentation rate, C-reactive protein, complement proteins, S100 proteins, cytokines (IFNs, CD40 ligand, soluble CD25, rheumatoid factors, interleukins, and TNF-α), and chemokines (CXCL13, CXCL10, CCL2, CXCL11, and CCL25). These inflammatory markers can be used as prognostic indicators for disease progression in pSS. In conclusion, the results from the studies reported in this review indicate that high levels of inflammatory markers may serve as markers for disease progression of pSS, which, in turn, may be valuable in predicting disease outcome.