Ultrasonic-assisted nanofiltration separation recovering salvianolic acid B from ethanol wastewater

作者：Cunyu Li, Yun Ma, Yangyang Xu, Ranyun Qiu, Xin Shen, Lulu Huang, Anrong Liu, Mingming Li, Yunfeng Zheng, Xinglei Zhi · 发表于：Ultrasonics Sonochemistry · 年份：2024 · DOI：10.1016/j.ultsonch.2024.106967 · 被引用次数：13 · 研究领域：Membrane Separation Technologies、Innovative Microfluidic and Catalytic Techniques Innovation、Microfluidic and Capillary Electrophoresis Applications

The transformation of salvianolic acid B brought on by heat treatment recovery of ethanol eluent, which is a difficult problem in pharmaceutical technology, affects the purity of raw material when the medicinal raw material salvianolic acid B is purified by resin. Ultrasonic-assisted nanofiltration separation (UANS) was first employed to improve efficiency of resource utilization by regulating rejection and separating salvianolic acid B and rosmarinic acid from organic pharmaceutical wastewater. The rejection was related to three variables: ultrasonic power, pH, and ethanol concentration. But there were differences in the effects of variables on the rejections of salvianolic acid B and rosmarinic acid. The rejections of rosmarinic acid and salvianolic acid B showed a decreasing trend with an increase in ultrasonic power or a decrease in pH; however, when the concentration of ethanol was increased from 5 % to 35 %, the salvianolic acid B rejection increased from 84.96 % to 96.60 % and the rosmarinic acid rejection decreased from 35.09 % to 17.51 %. On the basis of response surface methodology (RSM), the optimal UANS parameters for solution conditions involving different ethanol concentrations are as follows: 10 % ethanol solution (ultrasonic power 500 W and pH 6.15), 20 % ethanol solution (ultrasonic power 500 W and pH 6.54), and 30 % ethanol solution (ultrasonic power 460 W and pH 6.34). The molecular proportions of salvianolic acid B were 10.75 %, 7.13 %, and 8.27 % in 10 %,...