Quantitative US fat fraction for noninvasive assessment of hepatic steatosis in suspected metabolic-associated fatty liver disease

作者：Haohao Yin, Yunling Fan, Jifeng Yu, Bing Xiong, Boyang Zhou, Yi-Kang Sun, Lifan Wang, Yuli Zhu, Hui‐Xiong Xu · 发表于：Insights into Imaging · 年份：2024 · DOI：10.1186/s13244-024-01728-2 · 被引用次数：6 · 研究领域：Liver Disease Diagnosis and Treatment、Diabetes, Cardiovascular Risks, and Lipoproteins、Liver Disease and Transplantation

Abstract Objectives To evaluate the agreement between quantitative ultrasound system fat fraction (USFF) and proton magnetic resonance spectroscopy ( 1 H-MRS) and the diagnostic value of USFF in assessing metabolic-associated fatty liver disease (MAFLD). Methods The participants with or suspected of MAFLD were prospectively recruited and underwent 1 H-MRS, USFF, and controlled attenuation parameter (CAP) measurements. The correlation between USFF and 1 H-MRS was assessed using Pearson correlation coefficients. The USFF diagnostic performance for different grades of steatosis was evaluated using receiver operating characteristic curve analysis (ROC) and was compared with CAP, visual hepatic steatosis grade (VHSG). Results A total of 113 participants (mean age 44.79 years ± 13.56 (SD); 71 males) were enrolled, of whom 98 (86.73%) had hepatic steatosis ( 1 H-MRS ≥ 5.56%). USFF showed a good correlation (Pearson r = 0.76) with 1 H-MRS and showed a linear relationship, which was superior to the correlation between CAP and 1 H-MRS (Pearson r = 0.61). The USFF provided high diagnostic performance for different grades of hepatic steatosis, with ROC from 0.84 to 0.98, and the diagnostic performance was better than that of the CAP and the VHSG. The cut-off values of the USFF were different for various grades of steatosis, and the cut-off values for S1, S2, and S3 were 12.01%, 19.98%, and 22.22%, respectively. Conclusions There was a good correlation between USFF and 1 H-MRS. Meanwhile,...