Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity

作者：Wei Li, Rajesh Kushwaha, Tumpa Sadhukhan, Haorui Wu, Anyi Dao, Zhishang Zhang, Haotu Zhu, Qiufang Gong, Jiaxi Ru, Chao Liang, Pingyu Zhang, Samya Banerjee, Huaiyi Huang · 发表于：Journal of Medicinal Chemistry · 年份：2024 · DOI：10.1021/acs.jmedchem.4c00624 · 被引用次数：51 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Advanced biosensing and bioanalysis techniques

The design of the dinuclear Ru(II) complex ( Ru2 ) with strong near-infrared (NIR) absorption properties has been reported for efficient anticancer phototherapy. Under 700 nm LED light excitation, Ru2 exhibited remarkable synergistic type I/II photosensitization ability and photocatalytic activity toward intracellular biomolecules. Ru2 showed impressive 700 nm light-triggered anticancer activity under normoxia and hypoxia compared with the clinically used photosensitizer Chlorin e6. The mechanistic studies showed that Ru2 induced intracellular redox imbalance and perturbed the energy metabolism and biosynthesis in A549 cancer cells. Overall, this work provides a new strategy for developing efficient metal-based complexes for anticancer phototherapy under NIR light.