Synbiotic therapy with Clostridium sporogenes and xylan promotes gut-derived indole-3-propionic acid and improves cognitive impairments in an Alzheimer's disease mouse model

作者：Ling Li, Cong Yang, Mengzhen Jia, Yuhao Wang, Yu Zhao, Qingyuan Li, Jun Gong, Ying He, Kun Xu, Xuebo Liu, Xuhui Chen, Jun Hu, Zhigang Liu · 发表于：Food & Function · 年份：2024 · DOI：10.1039/d4fo00886c · 被引用次数：43 · 研究领域：Gut microbiota and health、Tryptophan and brain disorders、Probiotics and Fermented Foods

. Notably, synbiotic treatment also prevented the disruption of gut barrier integrity. Correlation analysis indicated a strong positive association between gut microbiota-generated IPA levels and behavioral changes. In conclusion, this study demonstrates that synbiotic supplementation significantly improves cognitive and intellectual deficits in 5xFAD mice, which could be partly attributed to enhanced IPA production by gut microbiota. These findings provide a theoretical basis for considering synbiotic therapy as a novel microbiota-targeted approach for the treatment of metabolic and neurodegenerative diseases.