Associations of serum uric acid variability with neuroimaging metrics and cognitive decline: a population-based cohort study

作者：Han Lv, Jing Sun, Tong Zhang, Ying Hui, Jing Li, Xinyu Zhao, Shuohua Chen, Wenjuan Liu, Xiaoshuai Li, Pengfei Zhao, Shouling Wu, Yanying Liu, Zhenchang Wang · 发表于：BMC Medicine · 年份：2024 · DOI：10.1186/s12916-024-03479-9 · 被引用次数：15 · 研究领域：Gout, Hyperuricemia, Uric Acid、Tryptophan and brain disorders、Inflammasome and immune disorders

BACKGROUND: The relationship between variation in serum uric acid (SUA) levels and brain health is largely unknown. This study aimed to examine the associations of long-term variability in SUA levels with neuroimaging metrics and cognitive function. METHODS: This study recruited 1111 participants aged 25-83 years from a multicenter, community-based cohort study. The SUA concentrations were measured every two years from 2006 to 2018. We measured the intraindividual SUA variability, including the direction and magnitude of change by calculating the slope value. The associations of SUA variability with neuroimaging markers (brain macrostructural volume, microstructural integrity, white matter hyperintensity, and the presence of cerebral small vessel disease) and cognitive function were examined using generalized linear models. Mediation analyses were performed to assess whether neuroimaging markers mediate the relationship between SUA variation and cognitive function. RESULTS: Compared with the stable group, subjects with increased or decreased SUA levels were all featured by smaller brain white matter volume (beta = - 0.25, 95% confidence interval [CI] - 0.39 to - 0.11 and beta = - 0.15, 95% CI - 0.29 to - 0.02). Participants with progressively increased SUA exhibited widespread disrupted microstructural integrity, featured by lower global fractional anisotropy (beta = - 0.24, 95% CI - 0.38 to - 0.10), higher mean diffusivity (beta = 0.16, 95% CI 0.04 to 0.28) and radial diffus...